Advertisement
Intelligent Drug Delivery System
Scope
Drug delivery refers to targeting drugs to specific body sites or precisely controlling drug release rates for prolonged times. This is generally realized by innovative drug delivery platforms and breakthrough drug delivery technologies. With the skyrocketing development of biomedical, material and pharmaceutical sciences, and the constant threats of malignant diseases, these drug delivery systems based on traditional nanomedicine are still hot topics. Especially, biomimetic cell membrane camouflage delivery and stimulus response delivery systems have acted as new platforms. Besides, many novel carriers such as microneedles, extracellular vesicles, and ionic liquids are rapidly emerging and becoming the forefront of drug delivery.
In this special issue, we invited world-wide renowned experts, such as endowed academicians, Clarivate highly cited researchers and distinguished young scholars, to cover the current advances of research on drug delivery platforms and technologies. We focus primarily on the principles and strategies employed for the design, synthesis, characterization, analysis, evaluation, and translation of novel drug delivery strategies for pre-clinical and clinical applications. It is envisioned that this issue can highlight the current advances and gain hints for the design and development of related drug delivery in the future.
Editor
Yuanjin Zhao
Deputy Editor, Health Science, Research
Southeast University, China
Table of Contents
- Although drug delivery systems (DDS) are efficient in brain delivery, they face failure in clinical settings due to their potential toxicity to the central nervous system. Little is known about where the DDS will go after brain delivery, and no specific ...
- Bradyarrhythmia is a kind of cardiovascular disease caused by dysregulation of cardiomyocytes, which seriously threatens human life. Currently, treatment strategies of bradyarrhythmia mainly include drug therapy, surgery, or implantable cardioverter ...
- Microneedle permits transdermal biosensing and drug delivery with minor pain. However, accurate microneedle transdermal positioning with minimal skin deformation remains a significant technical challenge due to inhomogeneous skin topology and ...
- Flowrate control in flexible bioelectronics with targeted drug delivery capabilities is essential to ensure timely and safe delivery. For neuroscience and pharmacogenetics studies in small animals, these flexible bioelectronic systems can be tailored to ...
- The transport and metabolism of lipids in cerebrovascular endothelial cells (ECs) have been hypothesized to regulate blood-brain barrier (BBB) maturation and homeostasis. Long-chain polyunsaturated fatty acids (LCPUFAs) as the important lipids components ...
- Thrombosis and infections are the two major complications associated with extracorporeal circuits and indwelling medical devices, leading to significant mortality in clinic. To address this issue, here, we report a biomimetic surface engineering strategy ...
- Rupture or erosion of inflammatory atherosclerotic vulnerable plaque is essential to acute coronary events, while the target intervene of vulnerable plaque is very challenging, due to the relatively small volume, high hemodynamic shear stress, and ...
- Self-propelled nanomotors have shown enormous potential in biomedical applications. Herein, we report on a nanozyme-powered cup-shaped nanomotor for active cellular targeting and synergistic photodynamic/thermal therapy under near-infrared (NIR) laser ...
- Radiofrequency (RF) catheter ablation has emerged as an effective alternative for the treatment of atrial fibrillation (AF), but ablation lesions will result in swelling and hematoma of local surrounding tissue, triggering inflammatory cell infiltration ...
- Tremendous progress has been made in the past decade regarding our understanding of the gut microbiome’s role in human health. Currently, however, a comprehensive and focused review marrying the two distinct fields of gut microbiome and material research ...
- Micromotors have demonstrated values in drug delivery, and recent attempts focus on developing effective approaches to generate functional micromotors to improve this area. Here, with the integration of microfluidic droplet printing and wettability-...
- Antibody-mediated rejection (ABMR) is a major cause of dysfunction and loss of transplanted kidney. The current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma cells. However, the prognosis of patients following ...
