BMEF
The Open Access journal BMEF (BME Frontiers), published in association with SIBET CAS, is a platform for the multidisciplinary community of biomedical engineering, publishing wide-ranging research in the field.
Latest Articles
Figure. A polypeptide (PCys2n)-based detoxification system for cisplatin (CDDP) that follows the 2-step administration principle. Reprinted with permission from [4]; copyright (2022) John Wiley & Sons.Since 2010, there has been a much greater awareness of the problem of intoxication, which has become the most common form of accidental and intentional death. In 2020, more than 90,000 people died of intoxication in the United States, which surpassed deaths due to motor vehicle accidents and firearms use to become the leading external cause of mortality. For clinical context, the causes of intoxication could be divided into 3 categories: (a) accidental ingestion of unknown xenobiotics, (b) excessive ingestion of bioactive molecules, and (c) inevitable toxicity arising from highly toxic medical drugs. However, the limited role of nonspecific extracorporeal techniques and the finite number of well-established antidotes are incapable of dealing with the complex emergencies arising from various forms of intoxication. Considering the modular properties of biocompatibility, binding affinity, biodistribution profile, and circulation time required to constitute a detoxification system, nanoantidotes would form a superior detoxification system more applicable to clinical practice [1].
Multidrug-resistant bacterial infections represent a dire threat to global health. The development of antibiotic resistance in bacteria coupled with the lack of development of new antibiotics is creating infections requiring antibiotics of last resort, ...
The interest in using therapeutic nanoparticles to bind with harmful molecules or pathogens and subsequently neutralize their bioactivity has grown tremendously. Among various nanomedicine platforms, cell membrane-coated nanoparticles, namely, “cellular ...
In the Research Article “A Low-Cost High-Performance Data Augmentation for Deep Learning-Based Skin Lesion Classification,” Zhihong Zhang was erroneously listed as an author. The PDF and HTML (full text) have been corrected.
Treatments for disease in the central nervous system (CNS) are limited because of difficulties in agent penetration through the blood-brain barrier, achieving optimal dosing, and mitigating off-target effects. The prospect of precision medicine in CNS ...
The effective treatment of patients with cancer hinges on the delivery of therapeutics to a tumor site. Nanoparticles provide an essential transport system. We present 5 principles to consider when designing nanoparticles for cancer targeting: (a) ...
Objective: A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy (PDT) has been designed.
Impact Statement: A site-specific conjugation of chlorin e6 (Ce6) to ferrimagnetic ferritin (MFtn-Ce6) ...
In the review article “Advances in In Vitro and In Vivo Bioreactor-Based Bone Generation for Craniofacial Tissue Engineering,” the authors made an error in Table. In Table, 10 cells in the Results column contain the word “enter,” which was erroneously added instead of starting a new line of text during proofing. This error did not affect the results, discussion, or conclusion of this paper. Table 1 has now been corrected in the PDF and HTML (full text).
Extensive effort has been devoted to the discovery, development, and validation of biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the response to therapeutic interventions. Genomic and transcriptomic profiling are well-...